Laboratory of Marine Biochemistry
(Fish Immunology/)



Division of Bioresource and Environmental Sciences
Graduate School, Kyushu University
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Current subjects

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Stuff

Students and other member

Contributions

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Current Subjects

  1. Structure, function, and molecular genetics of complement system in bony fish.
  2. Molecular cloning of bony fish cytokines and related factors.
  3. Development of immunostimulants for fish and their mode of action.
  4. Effects of heavy metals on aquatic organisms.

Stuff

Students and other member

BAYNE, Christopher (JSPS Visiting Fellow, Professor, Department of Zoology, Oregon State University)
"Molecular cloning of acute phase reactants in bony fish."

FUJIKI, Kazuhiro (JSPS PostDoc Fellow)
"Molecular cloning of cytokines and related factors from carp."

SHIN, Don-Ho (PhD student)
"Functional analysis of the NK cell-enhancing factor from carp."

KIMURA, Moritaka (PhD student)
"Structure and function of carp complement receptor type 3 (CR3)."

MUTSURO, Junichi (PhD student)
"Structural and functional diversity of the third complement component (C3) from carp."

KODAMA, Akiko (Master Course student)
"Assessment of mixture toxicity of many chemicals of the environmental quality standards for living of aquatic oarganisms."

TANAKA, Noriyuki (Master Course student)
"Molecular cloning of the fourth complement component (C4) from carp."

TANAKA, Yuichi (Master Course student)
"Characteristics of their tissue levels and tissue-specific distribution judged from element contents of fish tissues and algae."

KINOSHITA, Yujiro (Undergraduate student)
"Assessment of their combined mutagenicity using Salmonella mutagenicity test when many chemicals of the environmental quality standard coexist."

NAKAHARA, Makiko (Master Course student)

"Recombinant expression and functional analysis of the complement factor B/C2 from carp."

MIURA Chikako (Undergraduate student)
"Functional analysis of carp complement receptor type 3 (CR3)."

Contributions

Original papers

  1. Mutsuro J, Nakao M, Fujiki K, Yano T (2000) Multiple forms of alpha2-macroglobulin from a bony fish, the common carp (Cyprinus carpio): Striking sequence diversity in functional sites. Immunogenetics, 51, 847-855.
  2. Fujiki T, Shin DH, Nakao M, Yano T (2000) Molecular cloning and expression analysis of the putative carp (Cyprinus carpio) pre-B cell enhancing factor. Fish Shellfish Immunol. 10: 383-385.
  3. Fujiki T, Shin DH, Nakao M, Yano T (2000) Molecular cloning and expression analysis of carp (Cyprinus caprio) interleukin-1beta, high affinity immunoglobumin E Fc receptor gamma subunit and serum amyloid A. Fish Shellfish Immunol. 10: 229-241.
  4. T. Nagai, J. Mutsuro, M. Kimura, Y. Kato, K. Fujiki, T. Yano, M. Nakao (2000) A novel truncated isoform of the mannose-binding lectin-associated serine protease (MASP) from the common carp (Cyprinus carpio), Immunogenetics 51: 193-200
  5. Miki Nakao, Junichi Mutsuro, Rie Obo, Kazuhiro Fujiki, Masaru Nonaka, Tomoki Yano (2000) Molecular cloning and protein analysis of divergent forms of the complement component C3 from a bony fish, the common carp (Cyprinus carpio): presence of variants lacking the catalytic histidine. European J. Immunol., 30: 858-866
  6. Fujiki K, Shin DH, Nakao M, Yano T (1999) Molecular cloning of carp (Cyprinus carpio) CC chemokine, CXC chemokine receptors, allograft inflammatory factor-1 and natural killer cell enhancing factor by use of suppression subtractive hybridization. Immunogenetics 49: 909-914.
  7. Tomana M, Nakao M, Moritomo T, Fujiki K, Yano T (1999) Isolation of cDNA encoding immunoglobulin light chain from common carp (Cyprinus carpio L.). Fish Shellfish Immunol. 9: 71-80.
  8. Nakao M, Fushitani Y, Fujiki K, Nonaka M, Yano T (1998) Two diverged complement factor B/C2-like cDNA sequences from a teleost, the common carp (Cyprinus carpio). J. Immunol. 161: 4811-4818.
  9. Endo Y, Takahashi M, Nakao M, Saiga H, Seike H, Matsushita M, Nonaka M, Fujita T (1998) Two lineages of mannose-binding lectin-associated serine protease (MASP) in vertebrates. J. Immunol. 161: 4924-4930.
  10. Nakao M, Moritomo T, Tomana M, Fujiki K, Yano T (1998) Isolation of cDNA encoding constant region of the immunoglobulin heavy-chain from common carp (Cyprinus carpio L.). Fish Shellfish Immunol. 8: 425-434.
  11. Fujiki K, Yano T (1997) Effects of sodium alginate on the non-specific defence system of the common carp (Cypriuns carpio L.). Fish Shellfish Immunol. 7: 417-427.
  12. Fujiki K, Shin DH, Nakao M, Yano T (1997) Protective effect of kappa-carrageenan against bacterial infections in carp Cyprinus carpio. J. Fac. Agr., Kyushu Univ. 42: 113-119.
  13. Fujiki K, Shin DH, Nakao M, Yano T (1997) Effects of kappa-carrageenan on the non-specific defence system of carp Cyprinus carpio. Fish. Sci. 63: 934-938.
  14. Uemura T, Yano T, Shiraishi H, Nakao M (1996) Purification and characterization of the eighth and ninth components of carp complement. Mol. Immunol. 33: 925-932.
  15. Nakao M, Uemura T, Yano T (1996) Terminal components of carp complement constituting a membrane attack complex. Mol. Immunol. 33: 933-937.
  16. Nakao M, Tamai T, Murakami H, Yano T (1996) Monoclonal antibodies against the third component (C3) of carp complement. Fish. Sci. 62: 319-320.
  17. Yano T, Nakao M (1994) Isolation of a carp complement protein homologous to mammalian factor D. Mol. Immunol. 31: 337-342.
  18. Fujiki K, Matsuyama H, Yano T (1994) Protective effect of sodium alginates against bacterial infection in common carp, Cyprinus carpio L. J. Fish Dis. 17: 349-355.
  19. Nakagawa H, Tajima T, Sato T, Kuboyama M (1998) A field study of water lead pollution in fresh water areas of northern Kyushu, based on 5-aminolevulinic acid dehydratase activity and lead concentration in the blood of crucian carp Carassius auratus langsdorfii. J. Fac. Agr., Kyushu Univ. 43: 209-215.
  20. Kawakami Y, Mochiaka N, Morishita K, Tajima T, Nakagawa H, Toh H, Nakazono A (1998) Factors influencing otolith strontium/calucium ratios in Anguilla japonica elvers. Environ. Biol. Fish. 52: 299-303.
  21. Nakagawa H, Matsuo R, Sato T, Watanabe M (1997) Storage method for blood that provides stability of erythrocyte 5-aminolevulinic acid dehydratase of carp Cyprinus carpio when used as an indicator of water lead pollution. J. Fac. Agr., Kyushu Univ. 41: 215-221.
  22. Nakagawa H, Tajima T, Sato T, Watanabe M (1997) Evaluation of erythrocyte 5-aminolevulinic acid dehydratase activity in the blood of crucian carp Carassius auratus langsdorfii, as an indicator in fish of water lead pollution. J. Fac. Agr., Kyushu Univ. 41: 205-213.
  23. Nakagawa H, Sato T, Kubo H (1995) Evaluation of chronic toxicity of water lead for carp Cyprinus carpio using its blood 5-aminolevulinic acid dehydratase. Fish. Sci. 61: 956-959.
  24. Nakagawa K, Nakagawa H, Aso Y (1995) The type of inhibition of erythrocyte 5-aminolevulinic acid dehydratase in the blood of carp Cyprinus carpio caused by lead and cadmium. Sci. Bull. Fac. Agr., Kyushu Univ. 50: 51-57.
  25. Nakagawa H, Sato T, Kubo H (1995) Method not requring mercuric chloride for the determination of activity of 5-aminolevulininc acid dehydratase in blood of carp Cyprinus carpio. Fish. Sci. 61: 97-99.
  26. Nakagawa H, Nakagawa K, Sato T (1995) Evaluation of erythrocyte 5-aminolevulininc acid dehydratase activity in the blood of carp Cyprinus carpio as an indicator in fish with water lead pollution. Fish. Sci. 61: 91-95.
Reviews
  1. Nakao M, Yano T (1998) Structural and functional identification of complement components of the bony fish, carp (Cyprinus carpio). Immunol. Rev. 166: 27-38.
Monographs
  1. Yano T (1996) The nonspecific immune system: humoral defense. In "The fish immune system: organism, pathogen, and environment", Iwama G, Nakanishi T, eds. (Fish Physiology series, Vol. 15), pp. 105-157, Academic Press, San Diego, CA.

 

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Miki Nakao
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最終更新日: 99.1.20